mk 212 hydrochloride Search Results


mk212 hydrochloride  (Tocris)
92
Tocris mk212 hydrochloride
Effects of saline and 5–HT2C ligands on the consolidation of autoshaped-operant reinforced and nonreinforced responding in mice after 1-h (white bars) and 2-h (black bars) acquisitions sessions on day 1. Vertical axis: left panel, mean-adjusted latency defined as the latency to the tenth minus the latency to the first reinforced response; middle panel, rate of overall dipper hole nose-poke responses per second; right panel, rate of left and right nose-poke responding as a measure of nonreinforced activity. Horizonrtal axis: saline, drugs and doses in mg/kg, administered intraperitoneally. 1-h acquisition session: 32 mg/kg mianserin increased day 2 mean latency relative to saline controls (P < 0.001), <t>MK212</t> (P < 0.01), SB206 553 (P < 0.01), BOL (P < 0.05) and methysergide (P < 0.01) (left panel); reduced rates of reinforced responding relative to saline (P < 0.01) and 10 mg/kg SB206 553 (P < 0.01) (middle panel); MK212 increased nonreinforced response rates relative to 32 mg/kg mianserin (P < 0.05) and methysergide (P < 0.05) (right panel). 2-h acquisition session: 32 mg/kg mianserin increased day 2 mean latency relative to saline controls (P < 0.05) and all other agents tested (P < 0.05) (left panel); reduced rates of reinforced responding compared with saline controls (P < 0.05), m-chlorophenylpiperazine (mCPP) (P < 0.01), 3.2 mg/kg SB206 553 (P < 0.05) and methysergide (P < 0.01) (middle panel); 10 mg/kg SB206 553 significantly altered rates of nonreinforced responding relative to saline controls, (P < 0.05), MK212 (P < 0.01), mCPP (P < 0.05) and 32 mg/kg mianserin (P < 0.05) (right bars). Number of mice tested during the 1- and 2-h acquisition session, respectively: saline (n = 11, 10), MK212 (n = 5, 5), mCPP (n = 11, 12), (10 mg/kg n = 6, 6; 32 mg/kg n = 6, 9), SB206 553 (3.2 mg/kg n = 6, 4; 10 mg/kg n = 11, 5), BOL (n = 5, 7), and methysergide (n = 5, 9). Twelve mice failed to earn five (1 h) or 10 (2 h) reinforcers during the day 1aquisition session. Vertical bars represent SEM *P < 0.05; **P < 0.01; ***P < 0.001.
Mk212 Hydrochloride, supplied by Tocris, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mk+212+hydrochloride/pmc06511452-122-0-7?v=Tocris
Average 92 stars, based on 1 article reviews
mk212 hydrochloride - by Bioz Stars, 2026-07
92/100 stars
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mk 212  (Tocris)
93
Tocris mk 212
Effects of saline and 5–HT2C ligands on the consolidation of autoshaped-operant reinforced and nonreinforced responding in mice after 1-h (white bars) and 2-h (black bars) acquisitions sessions on day 1. Vertical axis: left panel, mean-adjusted latency defined as the latency to the tenth minus the latency to the first reinforced response; middle panel, rate of overall dipper hole nose-poke responses per second; right panel, rate of left and right nose-poke responding as a measure of nonreinforced activity. Horizonrtal axis: saline, drugs and doses in mg/kg, administered intraperitoneally. 1-h acquisition session: 32 mg/kg mianserin increased day 2 mean latency relative to saline controls (P < 0.001), <t>MK212</t> (P < 0.01), SB206 553 (P < 0.01), BOL (P < 0.05) and methysergide (P < 0.01) (left panel); reduced rates of reinforced responding relative to saline (P < 0.01) and 10 mg/kg SB206 553 (P < 0.01) (middle panel); MK212 increased nonreinforced response rates relative to 32 mg/kg mianserin (P < 0.05) and methysergide (P < 0.05) (right panel). 2-h acquisition session: 32 mg/kg mianserin increased day 2 mean latency relative to saline controls (P < 0.05) and all other agents tested (P < 0.05) (left panel); reduced rates of reinforced responding compared with saline controls (P < 0.05), m-chlorophenylpiperazine (mCPP) (P < 0.01), 3.2 mg/kg SB206 553 (P < 0.05) and methysergide (P < 0.01) (middle panel); 10 mg/kg SB206 553 significantly altered rates of nonreinforced responding relative to saline controls, (P < 0.05), MK212 (P < 0.01), mCPP (P < 0.05) and 32 mg/kg mianserin (P < 0.05) (right bars). Number of mice tested during the 1- and 2-h acquisition session, respectively: saline (n = 11, 10), MK212 (n = 5, 5), mCPP (n = 11, 12), (10 mg/kg n = 6, 6; 32 mg/kg n = 6, 9), SB206 553 (3.2 mg/kg n = 6, 4; 10 mg/kg n = 11, 5), BOL (n = 5, 7), and methysergide (n = 5, 9). Twelve mice failed to earn five (1 h) or 10 (2 h) reinforcers during the day 1aquisition session. Vertical bars represent SEM *P < 0.05; **P < 0.01; ***P < 0.001.
Mk 212, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mk+212+hydrochloride/pmc06589716-375-41-52?v=Tocris
Average 93 stars, based on 1 article reviews
mk 212 - by Bioz Stars, 2026-07
93/100 stars
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mk 212 hydrochloride  (Biosynth Carbosynth)
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mk 212 hydrochloride  (Aladdin Scientific Corporation)
N/A
Product description：MK-212 (CPP) monohydrochloride is a centrally acting 5-HT1C/5-HT2 agonist. MK-212 monohydrochloride can stimulate phosphoinositide hydrolysis in cerebral cortex.
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mk 212 hydrochloride  (TargetMol)
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mk 212 hydrochloride  (Santa Cruz Biotechnology)
N/A
MK 212 hydrochloride is a SR-2C agonist.
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Effects of saline and 5–HT2C ligands on the consolidation of autoshaped-operant reinforced and nonreinforced responding in mice after 1-h (white bars) and 2-h (black bars) acquisitions sessions on day 1. Vertical axis: left panel, mean-adjusted latency defined as the latency to the tenth minus the latency to the first reinforced response; middle panel, rate of overall dipper hole nose-poke responses per second; right panel, rate of left and right nose-poke responding as a measure of nonreinforced activity. Horizonrtal axis: saline, drugs and doses in mg/kg, administered intraperitoneally. 1-h acquisition session: 32 mg/kg mianserin increased day 2 mean latency relative to saline controls (P < 0.001), MK212 (P < 0.01), SB206 553 (P < 0.01), BOL (P < 0.05) and methysergide (P < 0.01) (left panel); reduced rates of reinforced responding relative to saline (P < 0.01) and 10 mg/kg SB206 553 (P < 0.01) (middle panel); MK212 increased nonreinforced response rates relative to 32 mg/kg mianserin (P < 0.05) and methysergide (P < 0.05) (right panel). 2-h acquisition session: 32 mg/kg mianserin increased day 2 mean latency relative to saline controls (P < 0.05) and all other agents tested (P < 0.05) (left panel); reduced rates of reinforced responding compared with saline controls (P < 0.05), m-chlorophenylpiperazine (mCPP) (P < 0.01), 3.2 mg/kg SB206 553 (P < 0.05) and methysergide (P < 0.01) (middle panel); 10 mg/kg SB206 553 significantly altered rates of nonreinforced responding relative to saline controls, (P < 0.05), MK212 (P < 0.01), mCPP (P < 0.05) and 32 mg/kg mianserin (P < 0.05) (right bars). Number of mice tested during the 1- and 2-h acquisition session, respectively: saline (n = 11, 10), MK212 (n = 5, 5), mCPP (n = 11, 12), (10 mg/kg n = 6, 6; 32 mg/kg n = 6, 9), SB206 553 (3.2 mg/kg n = 6, 4; 10 mg/kg n = 11, 5), BOL (n = 5, 7), and methysergide (n = 5, 9). Twelve mice failed to earn five (1 h) or 10 (2 h) reinforcers during the day 1aquisition session. Vertical bars represent SEM *P < 0.05; **P < 0.01; ***P < 0.001.

Journal: Behavioural pharmacology

Article Title: Acquisition session length modulates consolidation effects produced by 5–HT 2C ligands in a mouse autoshaping-operant procedure

doi: 10.1097/FBP.0b013e328337bde7

Figure Lengend Snippet: Effects of saline and 5–HT2C ligands on the consolidation of autoshaped-operant reinforced and nonreinforced responding in mice after 1-h (white bars) and 2-h (black bars) acquisitions sessions on day 1. Vertical axis: left panel, mean-adjusted latency defined as the latency to the tenth minus the latency to the first reinforced response; middle panel, rate of overall dipper hole nose-poke responses per second; right panel, rate of left and right nose-poke responding as a measure of nonreinforced activity. Horizonrtal axis: saline, drugs and doses in mg/kg, administered intraperitoneally. 1-h acquisition session: 32 mg/kg mianserin increased day 2 mean latency relative to saline controls (P < 0.001), MK212 (P < 0.01), SB206 553 (P < 0.01), BOL (P < 0.05) and methysergide (P < 0.01) (left panel); reduced rates of reinforced responding relative to saline (P < 0.01) and 10 mg/kg SB206 553 (P < 0.01) (middle panel); MK212 increased nonreinforced response rates relative to 32 mg/kg mianserin (P < 0.05) and methysergide (P < 0.05) (right panel). 2-h acquisition session: 32 mg/kg mianserin increased day 2 mean latency relative to saline controls (P < 0.05) and all other agents tested (P < 0.05) (left panel); reduced rates of reinforced responding compared with saline controls (P < 0.05), m-chlorophenylpiperazine (mCPP) (P < 0.01), 3.2 mg/kg SB206 553 (P < 0.05) and methysergide (P < 0.01) (middle panel); 10 mg/kg SB206 553 significantly altered rates of nonreinforced responding relative to saline controls, (P < 0.05), MK212 (P < 0.01), mCPP (P < 0.05) and 32 mg/kg mianserin (P < 0.05) (right bars). Number of mice tested during the 1- and 2-h acquisition session, respectively: saline (n = 11, 10), MK212 (n = 5, 5), mCPP (n = 11, 12), (10 mg/kg n = 6, 6; 32 mg/kg n = 6, 9), SB206 553 (3.2 mg/kg n = 6, 4; 10 mg/kg n = 11, 5), BOL (n = 5, 7), and methysergide (n = 5, 9). Twelve mice failed to earn five (1 h) or 10 (2 h) reinforcers during the day 1aquisition session. Vertical bars represent SEM *P < 0.05; **P < 0.01; ***P < 0.001.

Article Snippet: MK212 hydrochloride, mCPP hydrochloride, and methy-sergide maleate (Tocris Bioscience, Ellisville, Missouri, USA), mianserin hydrochloride, SB 206 553 hydrochloride (Sigma Aldrich, St. Louis, Missouri, USA), and BOL (National Institute on Drug Abuse, Bethesda, Maryland, USA).

Techniques: Saline, Activity Assay